Methylenetetrahydrofolate Reductase Deficiency Reduces Brain Microglia in Zebrafish During Embryonic Development and Is Not Corrected by Folic Acid
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منابع مشابه
Methylenetetrahydrofolate reductase C677T polymorphism does not alter folic acid deficiency-induced uracil incorporation into primary human lymphocyte DNA in vitro.
Methylenetetrahydrofolate reductase (MTHFR) is an enzyme which converts 5,10-methylene tetrahydrofolate (5,10-MnTHF) to 5-methyl tetrahydrofolate. A common C to T transition (C677T) in the MTHFR gene is reported to reduce the risk for colorectal cancer and acute lymphocytic leukemia in homozygotes (TTs). It is hypothesized that because TTs have reduced MTHFR activity, more 5,10-MnTHF is availab...
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Methylenetetrahydrofolate reductase (MTHFR) is an enzyme key regulator in folate metabolism. Deficiencies in MTHFR result in increased levels of homocysteine, which leads to reduced levels of S-adenosylmethionine (SAM). In the brain, SAM donates methyl groups to catechol-O-methyltransferase (COMT), which is involved in neurotransmitter analysis. Using the MTHFR-deficient mouse model the purpose...
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MR imaging showed severe atrophy and large areas without myelination in the brain of a girl with methylenetetrahydrofolate reductase deficiency. Proton MR spectroscopy revealed mild signal reduction of N-acetylaspartate. After treatment with betaine, a second MR imaging study revealed a decrease in the size of the hypomyelinated zones that was paralleled by improved clinical status and laborato...
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Besser, G. M., et al., British Medical Journal, 1972, 3, 669. 2Friesen, H., and Hwang, P., Annual Review of Medicine, 1973, 24, 251. 3Forbes, A. P., et al., Journal of Clinical Endocrinology and Metabolism, 1954, 14, 265. 4Hafiez, A. A., et al., Journal of Endocrinology, 1972, 52, 327. 5 Boyns, A. R., et al., in Prolactin and Carcinogenesis, ed. A. R. Boyns and K. Griffiths, p. 207. Cardiff, Al...
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ژورنال
عنوان ژورنال: Current Developments in Nutrition
سال: 2021
ISSN: 2475-2991
DOI: 10.1093/cdn/nzab049_038